A thin polymer film placed on the inner cheek (buccal mucosa) that hydrates and releases actives—often within 10–60 s—enabling unit-dose precision, discreet use, and potential mucosal absorption (active-dependent).
Where It Shines (Use Cases)
- Energy & focus: caffeine/theanine micro-doses for commuters.
- Sleep support: melatonin or botanicals at bedside.
- Oral care: breath-freshening, enamel/whitening adjuncts (market-dependent).
- Electrolytes & vitamins: pill-fatigued users, on-the-go.
- Pediatric/geriatric adherence: easy, water-free dosing.
Compliance note: Drug/OTC/nicotine actives require jurisdiction-specific approvals; examples here describe the format, not claims.
Formulation Snapshot
- Matrix: Pullulan / HPMC / PVA (solo or blends).
- Plasticizer: Glycerin or PEG-400 for flexibility.
- Taste system: Sweeteners (sucralose/acesulfame-K), acids (citric/malic), natural flavors.
- Targets: thickness 40–100 μm, disintegration ≤60 s, content uniformity RSD ≤3–5%.
Manufacturing (High Level)
- Polymer solution → add plasticizer/flavors → incorporate active → de-aerate.
- Cast to controlled coat weight → zoned drying to moisture window.
- Condition → slit → die-cut to size (e.g., 25×30 mm).
- Primary packaging: individual aluminum high-barrier sachets (low WVTR/OTR).
Packaging & Stability